Studies related to cancer treatment always contribute to the prevention and search for a cure for the disease. Here at Instituto Mário Penna we have qualified professionals who favor the emergence of new treatments for cancer patients. Physicist Jony Marques and radioconologist Dr. Arnoldo Mafra, both from the IMP, were part of an important research for the treatment of cancer, which obtained an international publication.
This research aims to develop and characterize a platform for in vitro cell irradiation. “For the treatment of cancer, there are numerous proposals for new drugs to increase the efficiency of the combined treatment of chemotherapy and radiotherapy. Before submitting patients to new treatments, they are initially tested on human cancer cells in studies called in vitro”; clarifies Jony Marques.
Those responsible for the study explain that as it is an in vitro study, it presents some problems, such as the fact that the cells do not receive a uniform dose of radiation, with typical uncertainties in the order of 25% or more. As all biological phenomena are dependent on the radiation dose received by the cells, large uncertainties in the dose values cause a loss of correlation between the dose variable and the effects caused, generating false or not fully understood results.
“Thus, the innovative proposal of this work brings the design of an acrylic platform, irradiated with clinical brachytherapy (the same that treats the gynecological patients of the IMP) and which reduces typical uncertainties of 25% in the dose value to something between 2 and 7 %, still proposing a correction factor to accurately obtain the radiation dose received by the cells”; explain.